AICAR 50mg
AMPK Activator Exercise Mimetic for Metabolic Research
AICAR (AICA Ribonucleotide) is a potent AMPK activator that mimics the metabolic effects of exercise — increasing fat oxidation, improving insulin sensitivity, and enhancing endurance capacity in animal models without physical exertion.
AMPK Activator Exercise Mimetic for Metabolic Research
AICAR is converted intracellularly to ZMP, an AMP analogue that activates AMPK — the master metabolic energy sensor. Research shows it replicates many biochemical adaptations of exercise training including mitochondrial biogenesis, glucose transporter upregulation, and fat oxidation.
As one of the most studied compounds in the metabolic & fat loss research space, AICAR has attracted sustained scientific interest across Exercise mimetic research, AMPK pathway studies, Metabolic syndrome research. Peer-reviewed evidence indicates that 44% endurance increase in mice without training, which has positioned AICAR as a reference standard for researchers exploring exercise mimetic research outcomes. The compound's selectivity and documented tolerability in preclinical models have contributed to a rapidly growing body of literature over the past decade.
AICAR Documented Benefits: 4 Documented Mechanisms
AMPK Activation
Directly activates the master metabolic regulator AMPK, triggering exercise-like metabolic responses.
Endurance Enhancement
Increases running endurance and oxidative capacity in animal models without training.
Insulin Sensitivity
Improves glucose uptake via GLUT4 translocation through AMPK activation.
Mitochondrial Biogenesis
Stimulates PGC-1α and mitochondrial proliferation via AMPK-SIRT1 pathway.
How AICAR Works: Molecular Mechanism & Pathway
Precursor to ZMP (AICAR monophosphate), which activates AMPK by mimicking elevated AMP:ATP ratio, triggering metabolic adaptations normally induced by exercise.
The 4 primary research pathways identified for AICAR — AMPK Activation, Endurance Enhancement, Insulin Sensitivity — collectively point to a compound with pleiotropic activity across interconnected biological systems. Studies have further shown that activates AMPK independently of actual energy deficit, reinforcing the mechanistic picture established in earlier cell-line work. Unlike single-pathway agents, AICAR's broad receptor engagement profile continues to generate hypotheses for novel applications beyond its originally characterized use cases.
Research Protocols & Compound Combinations
AICAR is routinely studied alongside NAD+ and MOTS-c in metabolic & fat loss-focused compound panels. Researchers investigating exercise mimetic research have found that pairing compounds with complementary receptor profiles can produce additive results while keeping individual doses within well-characterized ranges. Preliminary evidence that combined with GW501516 in landmark 'exercise in a pill' study has informed several of these multi-compound protocol designs.
Purity, Testing & Research Grade Standards
All AICAR research material offered through this catalog is manufactured under controlled conditions and independently verified by a third-party laboratory prior to release. Each lot undergoes High-Performance Liquid Chromatography (HPLC) analysis to confirm ≥98% purity, with identity confirmed via mass spectrometry. The accompanying Certificate of Analysis (CoA) documents the exact purity, molecular weight confirmation, and lot-specific testing date — data that should accompany any reproducible research protocol. Lyophilized powder formulation ensures maximum stability during shipping and storage at −20°C long-term or 4°C for short-term use.
◈ Key Highlights
- 44% endurance increase in mice without training
- Activates AMPK independently of actual energy deficit
- Combined with GW501516 in landmark 'exercise in a pill' study
Ideal For
- Exercise mimetic research
- AMPK pathway studies
- Metabolic syndrome research
- Endurance biology
Intended for laboratory use only. Not for human or animal consumption. Not FDA approved. Handle in appropriate lab settings only.
What the Research Shows
The following data points are derived from peer-reviewed preclinical and clinical studies on AICAR. All studies cited in compound profiles are indexed in PubMed or published in peer-reviewed journals.
44% endurance increase in mice without training
Activates AMPK independently of actual energy deficit
Combined with GW501516 in landmark 'exercise in a pill' study
Third-Party Verified Every Batch
Each vial of AICAR is independently tested by a third-party laboratory before fulfillment. You receive the actual CoA (Certificate of Analysis) documentation with your order.
