MOTS-c 10mg
Mitochondrial-Derived Peptide for Metabolic and Longevity Research
MOTS-c is a mitochondrial-derived peptide (MDP) encoded in the 12S rRNA that regulates glucose and lipid metabolism, improves insulin sensitivity, and extends lifespan in animal models. It functions as a mitochondria-to-nucleus retrograde signal coordinating cellular stress responses.
Mitochondrial-Derived Peptide for Metabolic and Longevity Research
MOTS-c activates AMPK and the FOXO pathway to regulate metabolic homeostasis. Exercise increases circulating MOTS-c levels, and research shows exogenous MOTS-c mimics many benefits of exercise on metabolism, mitochondrial function, and healthy aging.
As one of the most studied compounds in the recovery & healing research space, MOTS-c has attracted sustained scientific interest across Metabolic health research, Longevity studies, Mitochondrial biology. Peer-reviewed evidence indicates that extends lifespan in C. elegans models, which has positioned MOTS-c as a reference standard for researchers exploring metabolic health research outcomes. The compound's selectivity and documented tolerability in preclinical models have contributed to a rapidly growing body of literature over the past decade.
MOTS-c Documented Benefits: 4 Documented Mechanisms
Exercise Mimetic
Activates AMPK pathways similar to aerobic exercise, improving mitochondrial biogenesis and fat oxidation.
Insulin Sensitivity
Improves glucose uptake and insulin sensitivity in metabolic syndrome and diabetic models.
Lifespan Extension
Extends healthspan and lifespan in C. elegans and mouse aging models.
Muscle Metabolism
Enhances skeletal muscle energy efficiency and endurance in exercise research.
How MOTS-c Works: Molecular Mechanism & Pathway
Mitochondrial 12S rRNA-encoded peptide activating AMPK, FOXO, and SIRT1 pathways to coordinate metabolic stress responses and promote metabolic homeostasis.
The 4 primary research pathways identified for MOTS-c — Exercise Mimetic, Insulin Sensitivity, Lifespan Extension — collectively point to a compound with pleiotropic activity across interconnected biological systems. Studies have further shown that improves insulin sensitivity in diet-induced obesity models, reinforcing the mechanistic picture established in earlier cell-line work. Unlike single-pathway agents, MOTS-c's broad receptor engagement profile continues to generate hypotheses for novel applications beyond its originally characterized use cases.
Research Protocols & Compound Combinations
MOTS-c is routinely studied alongside NAD+ and MOTS-c in recovery & healing-focused compound panels. Researchers investigating metabolic health research have found that pairing compounds with complementary receptor profiles can produce additive results while keeping individual doses within well-characterized ranges. Preliminary evidence that circulates naturally in humans; levels decline with age has informed several of these multi-compound protocol designs.
Purity, Testing & Research Grade Standards
All MOTS-c research material offered through this catalog is manufactured under controlled conditions and independently verified by a third-party laboratory prior to release. Each lot undergoes High-Performance Liquid Chromatography (HPLC) analysis to confirm ≥98% purity, with identity confirmed via mass spectrometry. The accompanying Certificate of Analysis (CoA) documents the exact purity, molecular weight confirmation, and lot-specific testing date — data that should accompany any reproducible research protocol. Lyophilized powder formulation ensures maximum stability during shipping and storage at −20°C long-term or 4°C for short-term use.
◈ Key Highlights
- Extends lifespan in C. elegans models
- Improves insulin sensitivity in diet-induced obesity models
- Circulates naturally in humans; levels decline with age
Ideal For
- Metabolic health research
- Longevity studies
- Mitochondrial biology
- Exercise mimetic research
Intended for laboratory use only. Not for human or animal consumption. Not FDA approved. Handle in appropriate lab settings only.
What the Research Shows
The following data points are derived from peer-reviewed preclinical and clinical studies on MOTS-c. All studies cited in compound profiles are indexed in PubMed or published in peer-reviewed journals.
Extends lifespan in C. elegans models
Improves insulin sensitivity in diet-induced obesity models
Circulates naturally in humans; levels decline with age
Third-Party Verified Every Batch
Each vial of MOTS-c is independently tested by a third-party laboratory before fulfillment. You receive the actual CoA (Certificate of Analysis) documentation with your order.
