KPV 5mg
Anti-Inflammatory Tripeptide for IBD and Wound Healing Research
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH with potent anti-inflammatory properties. Research shows it inhibits NF-κB activation, reduces inflammatory cytokines, and heals intestinal inflammation in IBD models.
Anti-Inflammatory Tripeptide for IBD and Wound Healing Research
KPV retains the anti-inflammatory signaling of full-length α-MSH while being small enough to penetrate intestinal epithelium for local gut anti-inflammatory effects. It's been studied for Crohn's disease, ulcerative colitis, and skin wound healing.
As one of the most studied compounds in the recovery & healing research space, KPV has attracted sustained scientific interest across IBD and colitis research, Anti-inflammatory protocols, Wound healing studies. Peer-reviewed evidence indicates that reduces colitis severity in mouse models, which has positioned KPV as a reference standard for researchers exploring ibd and colitis research outcomes. The compound's selectivity and documented tolerability in preclinical models have contributed to a rapidly growing body of literature over the past decade.
KPV Documented Benefits: 3 Documented Mechanisms
NF-κB Inhibition
Blocks the master inflammatory transcription factor, reducing cytokine production downstream.
IBD Healing
Reduces intestinal inflammation and promotes mucosal healing in colitis models.
Wound Healing
Accelerates skin wound closure via anti-inflammatory and cell migration mechanisms.
How KPV Works: Molecular Mechanism & Pathway
C-terminal α-MSH tripeptide inhibiting NF-κB nuclear translocation via MC1R-independent pathways to reduce pro-inflammatory cytokine expression.
The 3 primary research pathways identified for KPV — NF-κB Inhibition, IBD Healing, Wound Healing — collectively point to a compound with pleiotropic activity across interconnected biological systems. Studies have further shown that inhibits NF-κB in intestinal epithelial cells, reinforcing the mechanistic picture established in earlier cell-line work. Unlike single-pathway agents, KPV's broad receptor engagement profile continues to generate hypotheses for novel applications beyond its originally characterized use cases.
Research Protocols & Compound Combinations
KPV is routinely studied alongside BPC-157 and KPV in recovery & healing-focused compound panels. Researchers investigating ibd and colitis research have found that pairing compounds with complementary receptor profiles can produce additive results while keeping individual doses within well-characterized ranges. Preliminary evidence that promotes wound healing in skin injury models has informed several of these multi-compound protocol designs.
Purity, Testing & Research Grade Standards
All KPV research material offered through this catalog is manufactured under controlled conditions and independently verified by a third-party laboratory prior to release. Each lot undergoes High-Performance Liquid Chromatography (HPLC) analysis to confirm ≥98% purity, with identity confirmed via mass spectrometry. The accompanying Certificate of Analysis (CoA) documents the exact purity, molecular weight confirmation, and lot-specific testing date — data that should accompany any reproducible research protocol. Lyophilized powder formulation ensures maximum stability during shipping and storage at −20°C long-term or 4°C for short-term use.
◈ Key Highlights
- Reduces colitis severity in mouse models
- Inhibits NF-κB in intestinal epithelial cells
- Promotes wound healing in skin injury models
Ideal For
- IBD and colitis research
- Anti-inflammatory protocols
- Wound healing studies
Intended for laboratory use only. Not for human or animal consumption. Not FDA approved. Handle in appropriate lab settings only.
What the Research Shows
The following data points are derived from peer-reviewed preclinical and clinical studies on KPV. All studies cited in compound profiles are indexed in PubMed or published in peer-reviewed journals.
Reduces colitis severity in mouse models
Inhibits NF-κB in intestinal epithelial cells
Promotes wound healing in skin injury models
Third-Party Verified Every Batch
Each vial of KPV is independently tested by a third-party laboratory before fulfillment. You receive the actual CoA (Certificate of Analysis) documentation with your order.
